Maxay yihiin sababaha keena cudurka psoriasis?

Sababaha keena cudurka psoriasis waxaa ka mid ah hidde-side, difaac, deegaan iyo arrimo kale, cudur-sidaha cudurkana weli si buuxda looma caddayn.

 1. Arrimaha hidde-sideyaasha

Daraasado badan ayaa muujiyay in arrimaha hidde-sideyaashu ay door muhiim ah ka ciyaaraan cudurka psoriasis. Taariikhda qoyska ee cudurkan waxay ka dhigan tahay 10% ilaa 23.8% bukaannada ku nool Shiinaha iyo qiyaastii 30% waddamada shisheeye.Suurtagalnimada in ilmo qaba cudurka psoriasis uu dhasho waa 2% haddii labada waalid midkoodna uusan qabin cudurka, 41% haddii labada waalidba ay qabaan cudurka, iyo 14% haddii hal waalid uu qabo cudurka.Daraasado lagu sameeyay mataano la xiriira cudurka psoriasis ayaa muujiyay in mataano monozygotic ah ay leeyihiin fursad 72% ah inay cudurka isku mar qaadaan, mataanaha dizygotic-na ay leeyihiin fursad 30% ah inay cudurka isku mar qaadaan. In ka badan 10 meelood oo loogu yeero meelaha nugul ayaa la aqoonsaday kuwaas oo si xooggan ula xiriira horumarinta cudurka psoriasis.

2. Arrimaha Difaaca Jirka

 Kicinta aan caadiga ahayn ee unugyada T-lymphocytes iyo ku-soo-gallaca epidermis ama maqaarka ayaa ah astaamo muhiim u ah cudurka psoriasis, taasoo soo jeedinaysa in habdhiska difaaca jirka uu ku lug leeyahay horumarka iyo horumarka cudurka.Daraasado dhowaan la sameeyay ayaa muujiyay in soo saarista IL-23 ee unugyada dendritic iyo unugyada kale ee soo bandhiga antigen-ka (APCs) ay keento kala soocid iyo faafinta unugyada caawiya CD4+ T lymphocytes, unugyada Th17, iyo unugyada Th17 ee bislaaday ee kala duwan ayaa soo saari kara noocyo kala duwan oo unugyo ah oo u eg Th17 sida IL-17, IL-21, iyo IL-22, kuwaas oo kiciya kororka xad dhaafka ah ee unugyada sameeya keratin ama jawaab celinta bararka ee unugyada synovial. Sidaa darteed, unugyada Th17 iyo dhidibka IL-23/IL-17 ayaa door muhiim ah ka ciyaari kara cudurka psoriasis.

3. Arrimaha Deegaanka iyo Dheef-shiid kiimikaadka

Arrimaha deegaanka ayaa door muhiim ah ka ciyaara kicinta ama sii xumeynta cudurka psoriasis, ama sii dheereynta cudurka, oo ay ku jiraan caabuqyada, walbahaarka maskaxda, caadooyinka xun (tusaale ahaan, sigaarka, khamriga), dhaawacyada, iyo falcelinta daawooyinka qaarkood.Bilaabashada cudurka psoriasis ee loo yaqaan 'pitting psoriasis' waxaa badanaa lala xiriiriyaa caabuqa ba'an ee streptococcal ee cunaha, daaweynta ka hortagga caabuqa waxay horseedi kartaa horumar iyo yareyn ama cafin nabarrada maqaarka. Cadaadiska maskaxda (sida walbahaarka, khalkhalka hurdada, shaqada xad dhaafka ah) waxay sababi kartaa in cudurka psoriasis uu dhaco, ka sii daro ama soo noqnoqodo, isticmaalka daaweynta soo jeedinta nafsiga ahna waxay yareyn kartaa xaaladda. Waxaa sidoo kale la ogaaday in dhiigkarka, sonkorowga, hyperlipidemia, cudurka halbowlaha wadnaha iyo gaar ahaan cilladda dheef-shiid kiimikaadka ay ku badan yihiin bukaanada qaba cudurka psoriasis.