Sababaha cudurka psoriasis waxaa ka mid ah hidda-socodka, difaaca jirka, deegaanka iyo arrimo kale, iyo cudur-gaarsiintiisa weli si buuxda uma cadda.
1. Arrimaha hiddaha
Daraasado badan ayaa muujiyay in arrimaha hiddaha ay door muhiim ah ka ciyaaraan cudurka psoriasis. Taariikhda qoyska ee cudurka ayaa ah 10% ilaa 23.8% bukaannada Shiinaha iyo ilaa 30% wadamo shisheeye.Suurtagalnimada in ilmo qaba cudurka psoriasis uu yahay 2% haddii labada waalid midkoodna uusan cudurka qabin, 41% haddii labada waalid ay qabaan cudurka, iyo 14% haddii hal waalid uu cudurka qabo.Daraasado lagu sameeyay mataanaha lala xiriiriyo cudurka psoriasis ayaa muujiyay in mataanaha monozygotic ay leeyihiin 72% suurtagalnimada inay cudurka isku mar qaadaan halka mataanaha dizygotic ay leeyihiin 30% suurtagalnimada inay cudurka isku mar qaadaan. In ka badan 10 waxa loogu yeero loci nuglaanta ayaa la aqoonsaday kuwaas oo si xoogan ula xiriira horumarka cudurka psoriasis.
2. Arrimaha difaaca jirka
Dhaqdhaqaaqa aan caadiga ahayn ee T-lymphocytes iyo qulqulka maqaarka epidermis ama maqaarka ayaa ah sifooyinka pathophysiological ee muhiimka ah ee cudurka psoriasis, oo soo jeedinaya ku lug lahaanshaha habka difaaca jirka ee horumarinta iyo horumarka cudurka.Daraasadihii ugu dambeeyay ayaa muujiyay in wax soo saarka IL-23 ee unugyada dendritic iyo unugyada kale ee antigen-soo bandhigaya (APCs) ay keenaan kala duwanaansho iyo kordhinta CD4 + caawiyayaasha T lymphocytes, unugyada Th17, iyo unugyada Th17 ee qaan-gaarka ah ayaa qarsoodi kara noocyo kala duwan oo Th17 ah oo la mid ah arrimaha unugyada sida sida IL-17, IL-21, iyo IL-22, taas oo kicinaysa kororka xad-dhaafka ah ee unugyada keratin-samaynta ama jawaabta bararka unugyada synovial. Sidaa darteed, unugyada Th17 iyo IL-23 / IL-17 dhidibka ayaa laga yaabaa inay door muhiim ah ka ciyaaraan cudurka psoriasis.
3. Arrimaha Deegaanka iyo Dheefshiidka
Arrimaha deegaanku waxay door muhiim ah ka ciyaaraan kicinta ama ka sii dara cudurka psoriasis, ama sii dheeraynta cudurka, oo ay ku jiraan caabuqyada, walbahaarka maskaxda, caadooyinka xun (tusaale, sigaar cabista, khamriga), dhaawacyada, iyo falcelinta daawooyinka qaarkood.Bilawga cudurka psoriasis ee goynta ayaa inta badan lala xiriiriyaa infekshanka streptococcal ee degdega ah ee pharynx, iyo daaweynta ka hortagga caabuqa waxay u horseedi kartaa horumar iyo hoos u dhac ama cafis nabarada maqaarka. Cadaadiska maskaxda (sida stress-ka, hurdo la'aanta, shaqada xad-dhaafka ah) waxay sababi kartaa cudurka psoriasis inuu dhaco, ka sii daro ama soo noqnoqdo, iyo isticmaalka daawaynta soo jeedinta nafsaaniga ah ayaa yarayn karta xaaladda. Waxa kale oo la ogaaday in hypertension, sonkorowga, hyperlipidemia, halbowlaha halbowlaha iyo gaar ahaan cilladda dheef-shiid kiimikaadka ay ku badan yihiin bukaannada cudurka psoriasis.
Waqtiga boostada: Mar-17-2023
